Pros and Cons of 5 Approved Prescriptions. For most people, the prescription for weight loss is pretty basic: Eat less, move more. In recent years, however, new drugs to combat obesity have moved onto the market. Journal of the American Medical Association (JAMA), highlights the promise and perils of each of these medications, which range from appetite suppressors to stimulants. Oz isn't a strong supporter of weight loss pills in general but does recommend a few natural supplements. Oz recommended diet pills. My physician has given me a prescription for Topamax for weight loss support. This program will be supervised and I will see the Dr weekly. An EKG and blood work were. If you can't diet or exercise it off, you can now try to freeze or zap it off. The Food and Drug Administration gave the green light for new weight loss treatments. They all must be accompanied by following a healthful diet and exercising, and their effects on the scale are moderate compared with the dramatic weight loss seen in people who undergo gastric bypass surgery, said Dr. Jill Jin, a general internist at the Northwestern Medical Group in Chicago, who wrote the article. However, Jin told Live Science, these medications can benefit certain patients. According to guidelines released by the Endocrine Society in January 2. BMI) of 3. 0 or higher. Medication Guides are available for these products: *biologic or drug/biologic combination. A new, injectable weight-loss drug has been approved by the U.S. Food and Drug Administration. The agency on Tuesday approved Saxenda (liraglutide) for adults who are. For most people, the prescription for weight loss is pretty basic: Eat less, move more. In recent years, however, new drugs to combat obesity have moved onto the. The Truth About HGH for Weight Loss. Can human growth hormone help you burn fat and build muscle? Drugs might also be helpful for people who are merely overweight (with a BMI of 2. If they don't lose at least 5 percent of their body weight after three months of use, they should discontinue using the drugs, according to the Endocrine Society. Weight loss benefits continue only as long as the drugs are taken, so users also need to develop healthy habits. Still, only five drugs (or drug combinations) have been approved by the Food and Drug Administration for the long- term treatment of obesity. Here's a brief rundown of each: Orlistat – Now available over- the- counter or as a prescription, orlistat was one of the first drugs in the weight- loss arsenal. It was first approved in 1. FDA for use with a prescription, and then in 2. The drug is sold under the brand name Xenical as a prescription and Alli as an over- the- counter drug. The drug is a lipase inhibitor, meaning it works to prevent the action of a pancreatic enzyme called lipase, which breaks down fat in the small intestine. Thus, taking orlistat with each meal prevents the absorption of all the fat from the food into the body. Reports of severe liver damage in about a dozen people who used orlistat prompted a new warning label in 2. The best weight loss supplements that work for both men and women. These 2 weight loss supplements are safe, natural & healthy.FDA could not confirm that the drug caused the damage. People who take the drug should watch for signs of liver malfunction such as yellow skin or eyes, itching, loss of appetite, brown urine or yellowish stool. However, the weight loss is likely to be modest. According to the Mayo Clinic, a 2. Alli for at least a year lost about 5. Lorcaserin – This drug acts on serotonin receptors in the brain to promote feelings of fullness, thus encouraging users to eat less. Approved in 2. 01. FDA nod since orlistat. According to the FDA, the drug (combined with diet and exercise) was associated with an average weight loss of 3 to 3. In patients without Type 2 diabetes, 3. Among patients who used diet and exercise alone, 2. The drug is not approved for pregnant women and can cause side effects such as drowsiness, headache and constipation. Phentermine is a stimulant that decreases appetite; topiramate is an anti- seizure and migraine drug that also decreases appetite and causes feelings of fullness. Another rare but serious side effect is the development of suicidal thoughts. According to the National Institutes of Health, about 1 in 5. In a clinical trial, patients who took this drug combo lost an average of 9 percent of their body weight, compared with 1. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. Two follow- up trials returned similar results for up to 2 years of use. Bupropion+naltrexone – Sold under the brand name Contrave, this drug combination first came into the spotlight in 2. It was rejected by the FDA because of concerns about its long- term effects on the heart and cardiovascular system. In 2. 01. 4, however, the agency gave Contrave the go- ahead — with the caveat that it will still be under scrutiny to ensure its cardiovascular safety. The drug was previously approved as a smoking cessation aid and to treat depression. Naltrexone had been used to treat alcohol and opioid addiction. Doctors aren't entirely sure how the drug combination works to promote weight loss. According to a 2. Pharmacy & Therapeutics, the drug's most likely targets are the hypothalamus, an almond- size region deep in the brain that controls hunger, and the mesolimbic reward system, a brain circuit that is involved in any rewarding activity, including eating. Those who dieted and exercised alone were less successful: Only 1. Liraglutide – This drug was first approved in 2. Type 2 diabetes. It helps promote insulin production in the pancreas, which in turn controls blood sugar. Sold as Saxenda, this version of the drug is a higher dose than that used to treat diabetes. Unlike the other FDA- approved drugs on this list, which are taken orally, Saxenda is taken as a once- a- day shot. This drug also has a black- box warning because rodent studies showed that it caused thyroid tumors. It's unknown whether liraglutide could have the same effect in humans, but people with a family history of certain cancers should not take the drug. Studies are ongoing to track the long- term safety of the drug in humans and in rats. Many people don't qualify to take them, either because they are not overweight enough, or because they have other health conditions or are taking other drugs that could make using these treatments unsafe. Follow us @livescience, Facebook& Google+. Original article on Live Science. 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